What substance is associated with panic reactions, often referred to as a bad trip?

Lysergic acid diethylamide, commonly known as LSD, is associated with panic reactions often referred to as a bad trip. This substance is a potent hallucinogen that significantly alters perception, mood, and cognitive processes. When users consume LSD, they may experience extreme changes in sensory perception, time distortion, and altered reality.

During these experiences, especially if the environment is not supportive or if the individual is predisposed to anxiety, panic reactions can occur. These reactions can manifest as intense fear, paranoia, and a feeling of losing control, making the psychedelic experience overwhelming and distressing. This is in stark contrast to the expected euphoric or enlightening effects that many seek from psychedelic substances, highlighting the unpredictable nature of LSD.

While other substances listed may also induce anxiety or negative experiences, LSD is specifically well-documented for the occurrence of panic-related reactions during its use. The unpredictable nature of the drug, combined with a person's psychological state, can lead to what is commonly termed a bad trip.